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Moscow and Toronto

Registered: Jun 2005
Posts: 1

Cell Division in Crypt - the computer simulation of cell proliferation

This probably can be of interest to the NKS community:

Cell Division Program, recently released.

This is the first animated computer simulation of cell proliferation in a living tissue. The program takes into account the long-neglected, although, well known fact that a living tissue represents an integral structure composed of interconnected cells and having a tissue-specific architectonics. In the program, the tissue is represented as a two-dimensional hexagonal lattice that can be curved and folded. Cell contacts within the lattice are permanent and are not broken by cell division. The program operates with two basic mechanisms: a) the division wave and b) the cell death (apoptosis) serving as an initiation point for cell division.

The program models cell proliferation, cell movement and cell growth in the crypt of intestinal epithelium. It can demonstrate the cell proliferation in a steady state, when cells are dividing, but the size of the crypt remains unchanged. It shows how the cells move along the crypt axis as a result of division waves propagating within the cell layer. In this process, the lattice undergoes peculiar transformations, rotating the direction of spiral rows of cells forming the crypt cylinder and changing the cell pattern but not the diameter of the cylinder.

The program allows modeling of other tissues with different structures. The rates of cell division and growth can be varied and the two processes can be uncoupled; this allows one to emulate certain cell patterns and shapes found in real tissues. Some structures will display growth and, in fact, will "develop" themselves, increasing their complexity. The model suggests a biological role of cell death (apoptosis). It also suggests proliferation patterns of stem cells that so far have escaped the attention of cell biologists.

This program can also serve as an excellent tool for classroom demonstration in Cell Biology.

Team at Cell Division Program
URL http://www.cell-division-program.com

Contact:
team@cell-division-program.com

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Old Post 06-27-2005 03:54 PM
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Gershom Zajicek M.D.
Hebrew University of Jerusalem
Jerusalem, Israel

Registered: Feb 2004
Posts: 152

Streaming Organism

All cells in the organism stream from the site of the stem cell where they are born to the tissue periphery where they die. In other words, all cells in the organism stream toward their graveyards. Heraclitus (500 BC) said that you never enter the same river twice. To which we add, you never meet the same individual twice, since all his cells stream.

My studies of Cell kinetics are summarized in the following address:
http://www.what-is-cancer.com/paper...eamorganism.htm

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Old Post 08-03-2005 01:29 PM
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meow44


Registered: Jun 2009
Posts: 1

simulation rachat de credit
this is an interesting topic. thanks for sharing

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Old Post 06-05-2009 05:59 PM
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